BP possesses minute cytotoxicity in-vitro and no toxicity in-vivo. These hydrogels could

be degraded and eliminated with urine. Additionally, the complexity of in-vivo appli­

cations affects the performance of bioelectronics based on 2D materials. The chemical

stability of biofluids under in-vivo configuration is different as compared to ambient

conditions. Apart from chemical stability, biofouling is a critical parameter that influences

device performance. Since the complex biological components deposited on the sensor

surface blocks the passage of target molecules. However, very few reports are available

related to the biofouling of bioelectronic devices. It is believed that the coating approach

might avoid problems associated with biofouling. Except for graphene, the exact inter­

action processes of 2D materials have seldom been documented, making full evaluations

of the relevant biological impacts challenging.

3.2.2 Shape Conformation

To achieve stable interfaces between biological and electronic components, conformal

electronic systems must be considered. The use of flexible and elastic substrates for 2D

materials permits successful interfacing at the cell or tissue level. Though it is thought-

provoking to conformably wrap complete organs (particularly the heart) to achieve a

FIGURE 3.3

(a) Schematic representation of BSA-MoS2 layer. (b) Comparison of biocompatibility in terms of the viability of

bulk as well as modified MoS2. (c) Bound amount of 2,4-D with bulk as well as modified MoS2. (d) Cyclic

voltammetry curves of bulk MoS2 and various polymer-adsorbed MoS2 nanosheets. Adapted with permission

[ 11]. Copyright (2015) American Chemical Society.

2D Materials for Bioelectronics

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